Recent study about Splenda Poisoning

Splenda and Sucralose Side Effects are Dangerous and Poisons

The tabletop version, Splenda contains other ingredients and bulking agents that have some side effects and carcinogenic potential and should not be confused with pure sucralose. But for this article we’ll deal with the pure version of Sucralose.

Few human studies of safety have been published on sucralose. One small study of diabetic patients using the sweetener showed a statistically significant increase in glycosylated hemoglobin (Hba1C), which is a marker of long-term blood glucose levels and is used to assess glycemic control in diabetic patients. According to the FDA, “increases in glycosolation in hemoglobin imply lessening of control of diabetes.

Research in animals has shown that sucralose can cause many problems in rats, mice, and rabbits, such as:

  • Shrunken thymus glands (up to 40% shrinkage)
  • Enlarged liver and kidneys
  • Atrophy of lymph follicles in the spleen and thymus
  • Increased fecal weight
  • Reduced growth rate
  • Decreased red blood cell count
  • Hyperplasia of the pelvis
  • Extension of the pregnancy period
  • Aborted pregnancy
  • Decreased fetal body weights and placental weights
  • Diarrhea

According to one source (Sucralose Toxicity Information Center), concerning the significant reduction in size of the thymus gland, “the manufacturer claimed that the sucralose was unpleasant for the rodents to eat in large doses and that starvation caused the shrunken thymus glands.

Toxicologist Judith Bellin reviewed studies on rats starved under experimental conditions, and concluded that their growth rate could be reduced by as much as a third without the thymus losing a significant amount of weight (less than 7 percent). The changes were much more marked in rats fed on sucralose. While the animals’ growth rate was reduced by between 7 and 20 percent, their thymuses shrank by as much as 40 percent.
(New Scientist 23 Nov 1991, pg 13)”

Sucralose, a high-intensity sweetener, is made from sugar so it tastes like sugar. This is accomplished using a patented multi-step process that selectively replaces three hydrogen-oxygen groups on the sugar molecule with three chlorine atoms. The result is an exceptionally stable sweetener that keeps sugars taste without sugars calories and carbohydrates. After consumption it passes through the body without being metabolized or broken down. Sucralose is approximately six hundred times sweeter than sugar, and as a result, only small amounts are necessary in a product.

Sucralose underwent the FDA’s rigorous food additive approval process, and in 1998, the FDA approved sucralose for use in 15 food and beverage categories, the broadest initial approval ever given to a food additive. The FDA has never required any warning label or information statements on products containing sucralose.

Sucralose has been approved for use in more than 40 countries worldwide. Canada approved sucralose in 1991, Australia and Mexico in 1993. Regulatory agencies have also approved the use of sucralose in Brazil, China, Japan, in various Latin American, Asian, Caribbean, and Middle Eastern countries. In 1990, the safety of sucralose was confirmed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). JECFA is an international body of experts whose safety evaluation of food additives is relied upon by the regulatory agencies of many smaller countries.

55 thoughts on “Splenda and Sucralose Side Effects are Dangerous and Poisons

  1. I always thought it was safer. I’ll definitely be looking into this. I use real sugar as much as possible (99.9% of the time) but there are times when I have used Splenda with others saying how helathy it is. Good to know…

  2. my grandmother’s a splenda addict and seems within 6 months of use one of her eyes have been giving her problems, making things appeared warped and other issues that the eye doctor thinks her eye had a bleed. She’s been treated, laid off the splenda for a bit, went back on and her eye is acting up again. She’s wondering if there’s a link, I say there’s an obvious link. The eye doctor can’t figure out the cause.

  3. I wrote a post not too long ago slamming V8 for putting sucralose in it’s V8 Splash beverage without any notation of it anywhere except in the very small list of ingredients. I’m glad to see other people acknowledging that Splenda is NOT the answer to our collective weight loss prayers.

    My post is here if you want to read it:

  4. Whenever I have anything with sucralose in it, I get a bad taste in my mouth lasting aproximately 8 hours. I know this is not psychosomatic because it happens when I consume some by accident and unknowingly. It is a big red flag to get me reading the fine print on whatever I recently had. It’s how I found out sucralose is in Airborne. Anyway, I was wondering if this happens to anyone else.

    • Splenda has helped me lose weight. It may not be proven safe or harmful yet, but being over weight has been prove to be dangerous to a person’s health. Could it be worth the trade off? And if you are one a a small minority who experience an offensive after taste (never had any such thing personally) and it is lasting as long as 8 hours, according to some – brush your teeth. It helps promote oral health as well!

    • I get the same thing – I try to avoid it – but recently accidentally had some light yogurt, light miracle whip and sugar free pickles – it leaves almost a metallic taste in my mouth that lasts LONG after I brush my teeth. Of course, now, I’m beginning to wonder if my toothpaste also contains splenda and I’ve missed it on the list of ingredients somehow? I never thought to look until I switched toothpastes and have noticed that I can’t get rid of the taste.
      It also makes me extremely strangely thirsty – apparently until I can wash the stuff out of my body.

      There are safer ways to lose weight than splenda. Such as cutting out the things that contain splenda completely. Soda is not good for you whether it has splenda or HFCS in it.

      I think I’m lucky that the artificial sweeteners all leave me with such a nasty taste that I would rather not have any sweetener in something than I would have the aftertaste. If I want something sweet – I have a small piece of something with real sugar – I just don’t have very much of it.

      at least with being overweight – you know the side effects. With this additive – you don’t know what they are.

    • yes this happens to me every time! it also makes my tongue feel like its three times its size and somewhat “furry’ in texture! i know this is not psychosomatic because like you, i would never consume it on pupose.

  5. I would like the citation of the research that is being referred to. All the research that I have found indicates no serious harmful side affects that are mentioned in this here with the exception of the atropy of the thymus and spleen nodes.

  6. The rat studies showing bad effects are because they use ridiculous amounts of sucralose over small period of time to “mimic” the normal use of it for years (40-50 years)
    Scientists are testing everything that way which I’m not sure it’s a good way of testing stuff as the human body adapts itself from everything thrown at it… If you feed someone with 2 pounds of sugar a day for 3 years in a row, that person will get sick and get a lot of problems but, feed the same person with the same amount of sugar, 3 pounds, over 20 years, not the same results… If it’s true that scientists are testing their stuff that way, we’re in a lot of troubles IMO….
    I suffer from diabetes and for me, splenda in small pouches is the way to go for my cofee and I won’t die because of it! I would if I used sugar!
    Bottom line!

    • sorry you feel that way…i still believe that anything that has had its molecules chemically altered is not good for our bodies and has high potential to cause cancer down the road…honey is a complete food full of vitamins and minerals, it’s antioxidant, antifungal, antibacterial and of course heals many cuts very quickly not too mention also kills the herpes virus in cold sores!…this is one of mother natures’ true sweeteners!…a 1/4 tsp. is all you need!

  7. Does anyone know of someone having “tingling” and feelings of an “insect biting” them on arms, legs and abdomen? I have these symptons and just thought of stopping sucralose!

    • Yes! I have had tingling of the skin anywhere from my head to my toes for months, also anxiety; I finally decided to eliminate all artificial sweetners/carbonation, and now I am back to normal – no tingling for several weeks!

  8. I’ve been selling a Candida Elimination Program that works and is inexpensive. Many people are getting well because of my showing them how to kill out yeast and fungus cheaply. Sucralose is a part of the cure. It’s strange that Canadians who have used sucralose, since 1991, aren’t complaining about having adverse reactions to it. They must not be having them.

  9. When this stuff started to get pushed on the American market, I immediately told my grandparents not to buy into it (even though I didn’t have facts to back it up). Knowing that the FDA approved Aspartame, which still is heavily on market, I knew it couldn’t be trusted. For all of you with Diabetes and other problems, the best solution is Agave syrup(comes from same plant as Tequila), Stevia, Honey or Maple Syrup. That’s 4 solid sweeteners that come from tree’s and plants and have absolutely no side effects. There is no excuse as to why you would choose any altered substances over these.

  10. While I realize Splenda is actually a commercial name for Sucralose, your article is confusing. In the first half you detail the dangers of Splenda, but in the second half, you describe Sucralose in a positive light i.e.: how it is made and been approved by health organizations.

  11. I think the point of the second half is that you cannot trust it just because it is FDA approved. Seeing the facts about it, then reading that the FDA approved it, should alarm us, correct?

  12. I tried a tiny bit of raspberry preserves with Sucralose in it, just to settle an argument and it tasted like hell. Splenda isn’t splendid. It’s horrid. Why do they add this crap to something already sweet and pure, like fruit preserves ????? Gag !

  13. Don’t use Splenda at all!

    I like to say sucralose, not Splenda, because that is what Splenda is. And it is in a lot of stuff Sadly, the package doesn’t have to say Splenda, or diet, to have sucralose in it. You have to read labels. So, you might still be using it and don’t even know it!

    A lot of people, including myself, have gotten/are getting sick from it.

    Many people don’t get any symptoms at all

    Sucralose is poison. It ruined five years of my life. I had a laundry list of medical problems while taking it. I went to several doctors. I had a dozen different tests. I was told that I had a number of different problems. I was on different medication for many years.

    The slogan, “Made from sugar…” is very misleading. Splenda might be made from sugar, but it is far from sugar. The resulting chemical is a class of chemicals called organochloride. Organochlorides are typically poisonous.

    carbon monoxide – made from oxygen so its like a breath of fresh air.

    Check out what others are saying

    Check out organochlorides

    Check out Duke University study

    More interesting Links

  14. almost everything today contains sucralose or some other
    artificial sweetner like stevia or lua hon etc. basicly you just have to
    read and research the product before you buy or just buy all natural

    • Stevia is not an artificial sweetener. It comes from the Stevia plant. Most artificial sweeteners give me a sore throat and headache. I have never had any problems with Stevia.

  15. I had terrible problems associated with Splenda. I got very depressed and terrible anxiety, with panic attacks. I ended up in the ER 4 times in the period of 3 months with heart racing, legs weak, light headedness. I thought I was having a heart attack. Also, had diarrhea, and lots lots lots of heart palpitations. Finally, when I realized that all this started after i started using splenda, i totally cut it out of my diet and read every label on everything to make sure there is no sucralose or splenda in it. It took months to get out of my system, and i finally stopped having the major panic attacks and anxiety after about a year. The point is, though, that not everyone reacts the same way. Some of us have a sensitivity or allergy to splenda and others can eat it and have no side effects. I wish, though, that doctors would ask a patient about any artificial sweeteners in his/her diet, instead of going through many er and doctor visits, testing, etc…. when if they would just tell the patient to stop consuming it for a few months to see if they improve, that may be all the person needs. I had to finally mention it to my doctor. And he said, “Oh, I didn’t think of asking you that, but it can cause a lot of problems in some patients. You should only eat natural substances, all those artificial sweeteners are not good for you.” WEll , DUH!!!

    • Melissa,

      I too had symptoms identical to yours. I stopped using sucralose in 2005.

      I never thought that ignorance was a prerequisite to being a doctor. But, it is.

      I know doctors, one of them a family member, who deem sucralose to be safe and completely ignore my story!

      I have not only stopped using sucralose, I only eat organic and/or all natural foods. I have to admit, as a 53 year old man, I feel the best today as I have felt in at least 20 years.

  16. Splenda is POISON. Period.

    Personally, it spikes my blood pressure to dangerous levels. I’m normally dead on the gold standard of 120/80. If I have even the smallest bit of sucralose, it jumps to 150/100 causing headaches, dizziness, irritability, malaise, etc. I’m a healthy 31 year old male with no prior health issues. I stopped the products with sucralose (propel water mainly) and I’ve NEVER had the issue again. I advise ANY patient that walks up to my pharmacy that Splenda is POISON and to NEVER use it.

    Donovan M. Haddix RPh

  17. Does anyone know of Sucralose being associated with short term memory loss? I’ve increased use of Splenda recently and have also experienced short term memory loss which concerns me.

  18. I’m a 59 year old male. Reasonably healthy. I’ve been using sucralose for years. I mail ordered it from Australia before it was available in the US. It tastes fine to me, and I don’t have any side effect. I have no doubt that some people hate the taste (my sister can’t stand it.) I always hated the taste of saccharin, while others just love it. And stevia leaves a rotten aftertaste in my mouth. So I don’t use those products. People react to things differently, and some people have a sensitivity to things that most don’t. If you are sensitive to sucralose, then don’t use it. It’s just that simple. As far as stevia and the other “natural” products being superior, what in the world does “natural” have to do with anything. Poison ivy is natural. Cyanide is natural. Hemlock (conium) is natural. Natural doesn’t automatically mean safe, either. Oh, and a question for the pharmacist who says sucralose is poison. Do you sell any Splenda, or sucrolose-sweeted products in you pharmacy? Hmmm. Thought so.

    • Let me give my opinion of what “natural” has to do with it.
      You are right, Poison Ivy, Cyanide, and Hemlock are all natural, poisonous and not safe. The difference is natural poisons affect you soon after you come into contact with them. Many chemicals were deemed safe at first and it took decades to see the damaging affects they had on the human body. I hope sucralose won’t be added to that list.
      Natural poisons are proven poisonous and unsafe right up front. Humans create chemicals and say they are safe. Decades later they are proven harmful and to me that’s not natural.

  19. It is amazing how many products this is turning up in if you read the labels. I don’t want my children eating it because I haven’t seen anything that would convince me that it is natural or safe for growing children with rapidly deviding cells. It is even named Sucralose to be intentionally deceiving, I believe. It sounds like Sucrose, and that’s just suguar, right? Those thymus, kidney and liver disorders were only in rats – but those are not carcinogenic, neurological, or reproductive risks, so don’t worry about your kids consuming it….did we mention the name is really close to Sucrose and that is just sugar?

  20. I think it should at least be required to have an allergy warning on labels if it is going to stick around. I’m about 99.9% sure, I’m allergic to sucralose..

    Just to name a few side effects, most commonly my tongue/throat will swell and burn or will feel like it itches, I’ll get sores in my mouth, I’ll experience (painful) abdominal pain, my blood pressure even dropped to low levels once. Ridiculous. I’ve found I can consume it in VERY small quantities (V8 Splash contains less than 2%, but I have to drink less than 8oz), but I still hate taking the risk.

    If they would maybe put it in bold like they do with milk and nut allergies, I think it’d make life a little easier for those who are allergic to it.

  21. I have used Splenda for years, in small amounts, as everything in moderation is a good motto, and I have had no side effects. Most of the symptoms explained above, especially the bad taste that does not go away after brushing, can also be symptoms of dieting.

    I expect that many people using sucralose or Splenda are likely to be on a diet for weight loss or other health reasons, as I was when I started using Splenda. Before criticising the product for all your ailments, I recommend that you review your diet first to ensure you are getting all your nutrients in the right quantities first.

    If your diet is not a problem and you’re still having problems digesting sucralose, don’t use it. Lots of people have problems digesting lots of foods, it doesn’t mean it’s poison. For example, I have problems digesting cucumbers, but I don’t call them poison, I just don’t eat them. My daughter is allergic to apples but she doesn’t call them poison and doesn’t request special labelling on packaged food that contain apple products.

    Regarding the diabetic who’s insulin spiked after using Splenda, it is a well documented fact that some people (not many) do respond to Splenda the same as if they had eaten sugar because it is made with sugar. If you are diabetic and get these symptons, don’t use it. You are only reacting as if you had consumed sugar which diabetics should not eat.

    Keep in mind that a healthy diet has a minimum of “junk” food so a large amount of sucralose should not be required. If you are consuming large quantities of it I recommend you re-evaluate your diet. You probably have more problems than just too much sucralose.

    I agree with DiabeticPatient and George. Apply logic and beware of fear mongers and those like Marcel who pass judgement before they have information. Also, I’d like to point out that honey and maple syrup are also dangerous for diabetics to use…”natural” doesn’t necessarily mean safe for many people.

    I recommend you use the product in moderation and listen to your own body.

  22. A few years ago I wanted to loose some weight and because I have a sweet tooth didn’t want to give up sugar. Splenda commercials stated it taste like sugar because it was made from sugar so I gave it a try. I started using it as a sweetener in my coffee, tea and nothing else. After a short time I stated getting sore’s on my legs that resembled large mosquito bites that itched and never went away. The problem with this is it was in the middle of winter and I live in Canada and it was minus 30 outside. After some time I became concerned and thought of seeing a doctor. I don’t like going to doctors so I decided to look over my life and see what I had changed recently that might be causing this. My conclusion was Splenda was the only thing different. I stopped using it and within a short time the sores went away and I haven’t had the problem since.
    Now I’m no expert but have come to the conclusion that any foods molecularly or chemically altered are plobably not good for us. We need to listen to our own bodies. I believe some people can use sucralose and some can’t just like I can eat peanuts while they can kill others.
    On a final note, I believe everyone must take responsibility for their own bodies and stop relying on doctors and others to tell them everything. The saying “you are what you eat” is so true.

  23. Everything ingested that is not life-sustaining ie man-made is a poison to the body (not recognizable by the body), including sugar.

  24. Man what a bunch of conspiracy theorist sheep. No relevant facts or scientifically vetted studies referred to in this article. Just a bunch of baseless accusations and inferences all backed up by an obvious distrust of regulatory organizations. Here we have the nature nuts pandering their wares, the hypochondriacs who feel tingling and metallic flavor which they attribute to the harm that it is causing their bodies, and 1 pseudo-web celebrity that spurns them on by stirring the pot occasionally. If you don’t like the product or experience something negative that you attribute to it then don’t buy it! Period. I am tired of having the web taken over by the fringe elements of society who, because of their collective handicaps, have nothing better to do than troll and post on blogs that should more realistically be categorized under the heading of humor/general misinformation.

  25. conspiracy theory, not here. But I can say it is the next best thing to a laxative for me. Times I’ve had drinks without realizing it’s got splenda. I figure it out about 15 minutes later when my stomach’s cramping and I and running for a bathroom. I check the bottle and yup, splenda. So that’s my 2 cents on why I won’t use it, lucky are the rest of you who can manage it.

  26. Rob, No conspiracy here.

    ’95, Sucralose was a laxative for for me as well. I remember the nights that I woke up in a deep sleep at 3AM-4AM with horrible cramps. Killed my night sleep. And many daytime issues. The doctor couldn’t help me.

    In addition to the laxative problem, Sucralose acted as a stimulate. After eating something with it in it, my heart would race. As a result, my sleep was affected.

  27. i am a very strong man and had been wondering what made my immune system weak, though i have habit of exercise, but i am also a food addict, and now i know what is source of my problem, i was on Sucralose to keep my weight down by eating a ton, i guess i was greedy, but not anymore, i want to live healthy; so i will just exercise more vigorously and get more strong

    compromised immune system is an invitation to all forms of infections.

    yes i am infected.

  28. Here in Canada sucralose is approved but I have a very hard time to find products without sugar and made with sucralose. Maybe because of you guys. I want sucralose !!!!!!!!!!!!!!!! Sugar makes me sick even in small amounts. If sucralose makes you sick – avoid it, it’s way easier than avoiding sugar which is in 99% of the food we eat.

    • I wish it was hard to find here. It’s in so many things now and sometimes if don’t read the ingredient list you would not know. Some things put it on the front so you know right away. They put it in pedialyte now! Went to buy it when my youngest was sick and I’m glad I decided to read the back. I get really ticked when companies use sugar and sucralose….pick one!

  29. Es, even the smallest amounts of sucralose causes problems for me. I don’t use it because I’m dieting; it just happens to pop up into several different food and drink products as the years go on and more and more brands hop on to the “sugar free” bandwagon. I don’t buy anything sweet without checking labels now. Never called it poison. On that note, comparing a sucralose allergy to an apple allergy is laughable… I guarantee that there are not as many products with possible traces of apple as there are with artificial sweeteners. Just saying, they do these things with nut, milk, wheat, and soy allergies, why not artificial sweeteners, since they are so frequently used?

    Rob, no one said you had to read any of this. No conspiracy theory here.

    Not even saying that the product should be banned. For those of you who can use it with no problems or would prefer to use it over anything else, excellent, keep buying the product then. There are those of us who simply can’t use it.

    Now for those who need a sugar substitute, and are not into Stevia, etc., I would suggest try saccharin (Sweet ‘n’ Low)? It has been in use the longest, and I’m not sure if there are side effects with its use, just from what I’ve read in my research and from personal experience, it seems to be the safest for human consumption. I have used it when I could not access sugar and I did not experience any side effects. It doesn’t have the most pleasant aftertaste but it’s not terribly noticeable, and a little goes a long way with it.

  30. Just recently developed a bad distortion in my field of vision in one eye and immediately thought it was sucrolose, as I have been consuming much more than normal. I am very in tune with my body, and I had noticed a HOST of the other symptoms many of you have shared on here. Weird tingling, itchy fingers, sore throat, very bad mouth ulcers, heightened anxiety… even pains from internal organs! I had been starting to put the pieces together, but the occular headache and subsequent vision failure cinched it for me.

    Reading other experiences makes me feel like less of an alarmist and more in tune with what my body is telling me. Since I stopped sucrolose? Everything is getting back to normal, save that my eye is slow to respond. It is improving very slowly, but surely. I might have just said “I’m getting older” or “my diet” or “stress,” but listening to what you are being told (by your body) can save a lot of trips to a physician.

    I dropped a LOT of weight – 120 pounds – with sucrolose as a minor player in that endeavor. When my consumption of it rose, recently, the problems came right to the forefront. They were always there, but rather muted and not so noticable.

    Bottom line for me: I cannot use this stuff in great quantities. But what’s it doing to me in even small quantities??? I do NOT want it any more!

      • Do you mean about the recent “problems?” No. I did just have a visit to my doctor about three weeks before this happened. Everything – blood pressure, O2 saturation, etc, etc was right on the money.

        I did speak to my eye doctor, who is also a friend. I told him about what was happening and answered all of his thorough questions. Though it could be any number of things happening with my eye, he believed it to be something I was taking: the steriod I had finished two weeks prior was a possibility, though remote. Possibly a different multivitamin.

        I will say that as of now, I am still doing much, much better with all the other issues that I had been having. The eye is still slowly improving.

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